Noggin Proteinfrom Abbexa |
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20-abx261827 | [ 1 mg: 5254.80 EUR ] [ 20 ug: 393.60 EUR ] [ 5 ug: 276.00 EUR ] | |
Noggin Proteinfrom Abbexa |
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20-abx261831 | [ 1 mg: 5254.80 EUR ] [ 20 ug: 393.60 EUR ] [ 5 ug: 276.00 EUR ] | |
Noggin proteinfrom Fitzgerald |
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30R-2674 | 20 ug: 450.00 EUR | |
Description: Purified recombinant Human Noggin protein |
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Noggin proteinfrom Fitzgerald |
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30R-AN039 | 20 ug: 327.60 EUR | |
Description: Purified recombinant Human Noggin protein |
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Noggin proteinfrom Fitzgerald |
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30R-AN040 | 20 ug: 327.60 EUR | |
Description: Purified recombinant Human Noggin protein |
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Noggin proteinfrom Bio-WORLD |
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22061198-1 | 20 µg: 260.20 EUR | |
Noggin protein (Mouse)from Fitzgerald |
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30R-AN047 | 20 ug: 327.60 EUR | |
Description: Purified recombinant Mouse Noggin protein |
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Human Noggin proteinfrom Abbkine |
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PRP100077-100ug | 100 μg: 1179.00 EUR | |
Description: Human Noggin protein, expressed in HEK293 Cells |
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Human Noggin proteinfrom Abbkine |
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PRP100077-1mg | 1 mg: 7139.00 EUR | |
Description: Human Noggin protein, expressed in HEK293 Cells |
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Human Noggin proteinfrom Abbkine |
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PRP100077-20ug | 20 μg: 469.00 EUR | |
Description: Human Noggin protein, expressed in HEK293 Cells |
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Noggin, HEK Proteinfrom Abbexa |
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20-abx262377 | [ 10 ug: 393.60 EUR ] [ 1 mg: 7676.40 EUR ] [ 2 µg: 276.00 EUR ] | |
OPPA00734-5UG - Noggin Proteinfrom Aviva Systems Biology |
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OPPA00734-5UG | 5ug: 70.00 EUR | |
OPPA01649-5UG - Noggin Proteinfrom Aviva Systems Biology |
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OPPA01649-5UG | 5ug: 70.00 EUR | |
Recombinant Human NOGGIN Proteinfrom BosterBio |
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PROTQ13253-3 | 20ug: 380.40 EUR | |
Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked homodimer (120-10C) consisting of two 206 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions. |
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Recombinant human Noggin Proteinfrom Abclonal |
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RP01237 | 10 μg: 219.60 EUR | |
Recombinant human Noggin Proteinfrom Abclonal |
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RP01228 | 20 μg: 260.40 EUR | |
Recombinant Human Noggin Proteinfrom EnoGene |
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E40KMP2049 | 20ug: 495.00 EUR | |
Recombinant Murine Noggin Proteinfrom BosterBio |
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PROTP97466-1 | 20ug: 380.40 EUR | |
Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. |
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Rat Noggin (NOG) Proteinfrom Abbexa |
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20-abx068319 | [ 100 ug: 828.00 EUR ] [ 10 ug: 343.20 EUR ] [ 1 mg: 2532.00 EUR ] [ 200 ug: 978.00 EUR ] [ 50 ug: 594.00 EUR ] | |
Pig Noggin (NOG) Proteinfrom Abbexa |
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20-abx068322 | [ 100 ug: 811.20 EUR ] [ 10 ug: 343.20 EUR ] [ 1 mg: 2498.40 EUR ] [ 200 ug: 961.20 EUR ] [ 50 ug: 577.20 EUR ] | |
Dog Noggin (NOG) Proteinfrom Abbexa |
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20-abx068323 | [ 100 ug: 811.20 EUR ] [ 10 ug: 343.20 EUR ] [ 1 mg: 2498.40 EUR ] [ 200 ug: 961.20 EUR ] [ 50 ug: 577.20 EUR ] | |
Rat Noggin (NOG) Proteinfrom Abbexa |
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20-abx068324 | [ 100 ug: 828.00 EUR ] [ 10 ug: 343.20 EUR ] [ 1 mg: 2532.00 EUR ] [ 200 ug: 978.00 EUR ] [ 50 ug: 594.00 EUR ] | |
Noggin Recombinant Proteinfrom ProSci |
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40-207-0005mg | 0.005 mg: 311.10 EUR | |
Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked homodimer (120-10C) consisting of two 206 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions. |
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Noggin Recombinant Proteinfrom ProSci |
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40-207-002mg | 0.02 mg: 437.10 EUR | |
Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked homodimer (120-10C) consisting of two 206 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions. |
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Noggin Recombinant Proteinfrom ProSci |
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40-445-0005mg | 0.005 mg: 311.10 EUR | |
Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. |
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Noggin Recombinant Proteinfrom ProSci |
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40-445-002mg | 0.02 mg: 437.10 EUR | |
Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. |
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Noggin Recombinant Proteinfrom ProSci |
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96-560 | 0.1 mg: 714.30 EUR | |
Description: Noggin is also known as NOG,SYM1, SYNS1 and is a secreted homodimeric glycoprotein whose scaffold contains a cystine-knot topology similar to that of BMPs.Secreted Noggin probably remains close to the cell surface due to its binding of heparincontaining proteoglycans.Noggin inhibits TGF-β signal transduction by binding to TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion. During embryogenesis, Noggin antagonizes specific BMPs at defined times, for example, during neural tube, somite and cardiomyocyte growth and patterning. During skeletal development, Noggin prevents chondrocyte hyperplasia, thus allowing proper formation of joints. During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons Noggin also appears to maintain adult stem cell populations in vivo, for example, maintaining neural stem cells within the hippocampus. |
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Human Noggin (NOG) Proteinfrom Abbexa |
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20-abx068317 | [ 100 ug: 594.00 EUR ] [ 10 ug: 292.80 EUR ] [ 1 mg: 1696.80 EUR ] [ 200 ug: 693.60 EUR ] [ 50 ug: 427.20 EUR ] | |
Mouse Noggin (NOG) Proteinfrom Abbexa |
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20-abx068318 | [ 100 ug: 727.20 EUR ] [ 10 ug: 309.60 EUR ] [ 1 mg: 2163.60 EUR ] [ 200 ug: 861.60 EUR ] [ 50 ug: 526.80 EUR ] | |
Chicken Noggin (NOG) Proteinfrom Abbexa |
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20-abx068321 | [ 100 ug: 910.80 EUR ] [ 10 ug: 360.00 EUR ] [ 1 mg: 2865.60 EUR ] [ 200 ug: 1095.60 EUR ] [ 50 ug: 644.40 EUR ] | |
Rat Noggin (NOG) Protein (Active)from Abbexa |
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20-abx651423 | [ 100 ug: 1128.00 EUR ] [ 10 ug: 410.40 EUR ] [ 1 mg: 3700.80 EUR ] [ 200 ug: 1362.00 EUR ] [ 50 ug: 777.60 EUR ] | |
Rat Noggin (NOG) Protein (Active)from Abbexa |
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20-abx651424 | [ 100 ug: 944.40 EUR ] [ 10 ug: 360.00 EUR ] [ 1 mg: 2983.20 EUR ] [ 200 ug: 1128.00 EUR ] [ 50 ug: 661.20 EUR ] | |
Noggin Mouse Recombinant Proteinfrom BosterBio |
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PROTP97466 | Regular: 20ug: 380.40 EUR | |
Description: Noggin Mouse Recombinant produced in E.Coli is a non-glycosylated, disulfide-linked protein consisting of two 206 amino acid polypeptide chains, having a total molecular mass of approximately 46.4 kDa (each chain 23.2 kDa). |
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Noggin Human Recombinant Proteinfrom BosterBio |
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PROTQ13253-1 | Regular: 20ug: 380.40 EUR | |
Description: Noggin Human Recombinant produced in E.Coli is a non-glycosylated, non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains, having a total molecular mass of approximately 46.2 kDa (each chain 23.1 kDa).;Noggin is purified by proprietary chromatographic techniques. |
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Recombinant human Noggin Protein, His Tagfrom EnoGene |
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E40KMP1352 | 20ug: 495.00 EUR | |
Recombinant human Noggin Protein, His Tagfrom EnoGene |
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E40KMP1354 | 20ug: 495.00 EUR | |
Recombinant Human Noggin protein (NOG) (Active)from Cusabio |
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CSB-AP003011HU | 8461 mg: Ask for price | |
Recombinant Human Noggin protein(NOG) (Active)from SAB |
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AP73539 | 1mg: 5119.00 EUR | |
Human Noggin (NOG) Protein (Active)from Abbexa |
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20-abx655789 | [ 100 ug: 927.60 EUR ] [ 10 ug: 360.00 EUR ] [ 1 mg: 2899.20 EUR ] [ 200 ug: 1095.60 EUR ] [ 50 ug: 644.40 EUR ] | |
Rabbit Anti-Human Noggin protein antiserumfrom Alpha Diagnostics |
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NOGN13-S | 100 ul: 548.40 EUR | |
Human Noggin Protein, Fc Tag, premium gradefrom ACROBIOSYSTEMS |
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NON-H5257 | 1mg: 107.00 EUR | |
Description: Human Noggin Protein, Fc Tag, premium grade (NON-H5257) is expressed from human 293 cells (HEK293). It contains AA Gln 28 - Cys 232 (Accession # Q13253-1). |
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Human Noggin Protein (Gln 28-Cys 232) [Fc]from Creative Biolabs |
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VAng-2617Lsx-100g | 100 µg: 1182.00 EUR | |
Description: Human Noggin protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: NP_005441) |
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Human Noggin Protein (Gln 28-Cys 232) [Fc]from Creative Biolabs |
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VAng-2617Lsx-1mg | 1 mg: 7186.80 EUR | |
Description: Human Noggin protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: NP_005441) |
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Recombinant Mouse Noggin/NOG Proteinfrom Abclonal |
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RP00480 | 10 μg: 208.80 EUR | |
Human Noggin Protein, premium grade (MALS verified)from ACROBIOSYSTEMS |
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NON-H5219 | 20ug: 2814.10 EUR | |
Description: Human Noggin Protein, premium grade (NON-H5219) is expressed from human 293 cells (HEK293). It contains AA Gln 28 - Cys 232 (Accession # Q13253-1). |
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NOGGIN Recombinant Protein (Animal Free)from ProSci |
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40-747 | 5 ug: 323.70 EUR | |
Description: Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures. Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant Murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. |
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Recombinant Mouse Noggin Protein, Untagged, E.coli-1mgfrom EnQuireBio |
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QP10795-1mg | 1mg: 4287.60 EUR | |
Recombinant Mouse Noggin Protein, Untagged, E.coli-5ugfrom EnQuireBio |
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QP10795-5ug | 5ug: 186.00 EUR | |
Recombinant Mouse Noggin Protein, Untagged, E.coli-20ugfrom EnQuireBio |
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QP10795-20ug | 20ug: 241.20 EUR | |
Mouse Noggin Recombinant Protein Lyophilizedfrom Innovative research |
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IMSNGGNRLY5UG | each: 341.00 EUR | |
Description: Mouse Noggin Recombinant Protein Lyophilized |
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Human Noggin Recombinant Protein Lyophilizedfrom Innovative research |
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IHUNGGNRLY5UG | each: 341.00 EUR | |
Description: Human Noggin Recombinant Protein Lyophilized |
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Active Recombinant Mouse Noggin/NOG Proteinfrom Abclonal |
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RP01308 | 100μg: 97.50 EUR | |
Human/ mouse Noggin protein Control/blocking peptide # 1from Alpha Diagnostics |
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NOGN11-P | 100 ug: 196.80 EUR | |
Human/ mouse Noggin protein Control/blocking peptide # 2from Alpha Diagnostics |
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NOGN12-P | 100 ug: 196.80 EUR | |
Human, Noggin Human Recombinant Protein, HEKfrom BosterBio |
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PROTQ13253 | Regular: 10ug: 380.40 EUR | |
Description: Noggin Human Recombinant produced in HEK cells is a glycosylated homodimer, having a total molecular weight of 65kDa.;The Noggin is purified by proprietary chromatographic techniques. |
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Human, Noggin Human Recombinant Protein, Sf9from BosterBio |
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PROTQ13253-2 | Regular: 5ug: 380.40 EUR | |
Description: Noggin produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 211 amino acids (28-232a.a.) and having a molecular mass of 23.8kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).; Noggin is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques. |
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Recombinant Mouse Noggin Protein with His tag, His Tagfrom EnoGene |
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E40KMP1876 | 20ug: 495.00 EUR | |
Nogginfrom BPS Bioscience |
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90256-1 | 10 µg: 120.00 EUR | |
Description: Human Noggin, also known as symphalangism 1 (SYM1) or synostoses (multiple) syndrome 1 (SYNS1), GenBank Accession No. NM_005450, a.a. 28-232(end), disulfide-linked homodimer. MW=~28kDa (monomer), expressed in Freestyle 293F cells. |
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Nogginfrom BPS Bioscience |
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90256-2 | 50 µg: 375.00 EUR | |
Description: Human Noggin, also known as symphalangism 1 (SYM1) or synostoses (multiple) syndrome 1 (SYNS1), GenBank Accession No. NM_005450, a.a. 28-232(end), disulfide-linked homodimer. MW=~28kDa (monomer). Source: human 293 cells. Endotoxin Level: <1 EU/µg. Biological Activity: measured by Noggin's ability to inhibit BMP-4-induced alkaline phosphatase production by C2C12 mouse myoblast cells. The ED50 is < 20 ng/ml in the presence of 30 ng/ml of human BMP-4. Formulation: Lyophilized from a 0.2 µM filtered, aqueous solution. Reconstitution: Supplied as a lyophilized solid. Reconstitute in sterile water with 0.1% BSA to a final concentration of 0.1 mg/ml. Final formulation will be 50 mM Tris, pH 8.0, 1.2 M NaCl, 2.7 mM KCl, 0.1% BSA. |
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Nogginfrom Neuromics |
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PR27117 | 5 ug: 229.20 EUR | |
Nogginfrom Neuromics |
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GT15159 | 100 ug: 631.20 EUR | |
Nogginfrom ProSpec Tany |
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cyt-475 | 5µg: 60.00 EUR | |
Description: Recombinant Human Noggin |
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Nogginfrom Neuromics |
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RA19066 | 100 ul: 490.80 EUR | |
Nogginfrom EnoGene |
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E8ER1802-30 | 100ul: 275.00 EUR | |
Description: Available in various conjugation types. |
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Nogginfrom SAB |
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AP85705 | 1mg: 2640.00 EUR | |
Nogginfrom SAB |
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AP86105 | 1mg: 2640.00 EUR | |
Nogginfrom SAB |
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AP86154 | 1mg: 2640.00 EUR | |
Nogginfrom SAB |
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AP78662 | 1mg: 2640.00 EUR | |
Human Recombinant purified Noggin protein, W. blot +ve controlfrom Alpha Diagnostics |
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NOGN11-C | 100 ul: 343.20 EUR | |
Recombinant Human Noggin / NOG Protein, Fc His Tagfrom EnoGene |
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E40KMP1462 | 20ug: 495.00 EUR | |
Human Recombinant (E.Coli) Purified Noggin protein, biologically activefrom Alpha Diagnostics |
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NOGN15-R-20 | 20 ug: 562.80 EUR | |
Noggin Recombinant Protein C-Fc Tag Lyophilizedfrom Innovative research |
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INOGGRCFCLY100UG | each: 851.00 EUR | |
Description: Noggin Recombinant Protein C-Fc Tag Lyophilized |
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Noggin/NOGfrom EnoGene |
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E21-018 | 10ug: 411.60 EUR | |
Noggin/NOGfrom EnoGene |
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E21-028 | 10ug: 411.60 EUR | |
Mouse Recombinant Purified Noggin protein (E. coli), biologically activefrom Alpha Diagnostics |
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NOGN26-R-20 | 20 ug: 781.20 EUR | |
Mouse Recombinant Purified Noggin protein (E. coli), biologically activefrom Alpha Diagnostics |
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NOGN26-R-5 | 5 ug: 343.20 EUR | |
Noggin, Sf9from ProSpec Tany |
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cyt-1119 | 2µg: 60.00 EUR | |
Description: Recombinant Human Noggin, Sf9 |
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Noggin, HEKfrom ProSpec Tany |
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cyt-977 | 1µg: 60.00 EUR | |
Description: Recombinant Human Noggin, HEK |
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NOGGIN, humanfrom Bio Basic |
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RC219-20 | 5ug: 125.26 EUR | |
Mouse NOGGIN Recombinant Protein (Animal Free) Lyophilizedfrom Innovative research |
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IMSNGGNRAFLY5UG | each: 333.00 EUR | |
Description: Mouse NOGGIN Recombinant Protein (Animal Free) Lyophilized |
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Noggin antibodyfrom Fitzgerald |
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20R-2935 | 100 ul: 471.60 EUR | |
Description: Rabbit polyclonal Noggin antibody |
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Noggin antibodyfrom Fitzgerald |
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20R-1856 | 100 ug: 807.60 EUR | |
Description: Rabbit polyclonal Noggin antibody |
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Noggin antibodyfrom Fitzgerald |
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70R-NR025 | 100 ug: 360.00 EUR | |
Description: Affinity purified Rabbit polyclonal Noggin antibody |
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Noggin Antibodyfrom Biovision |
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5775-100 | each: 379.20 EUR | |
Noggin Antibodyfrom Biovision |
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5775-30T | each: 175.20 EUR | |
Noggin antibodyfrom Fitzgerald |
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70R-12434 | 100 ug: 483.60 EUR | |
Description: Rabbit polyclonal Noggin antibody |
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Noggin antibodyfrom Fitzgerald |
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70R-4585 | 50 ug: 560.40 EUR | |
Description: Rabbit polyclonal Noggin antibody raised against the middle region of NOG |
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Noggin Antibodyfrom NSJ Bioreagents |
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R32957 | 100 ug: 356.15 EUR | |
Description: The secreted polypeptide, encoded by NOG gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. |